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observed that dynorphin A (1-17) and U50,488 promote the highest phosphorylation, etorphine 50% of the maximum and levorphanol failed to induce [ 32 P] incorporation demonstrating that opioid agonists have different potencies to phosphorylate this receptor (Li et al., 2003)

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One of the alleles, lag-1(ozIs43) was chosen to generate strain BS1193 ( S1 Table ) and used for germline LAG-1 ChIP-seq analysis ( Fig 4 )

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Therefore, bremelanotide also demonstrates why receptor pharmacology must be considered as a complete benefit-risk system