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Regional Disciplinary Medical Board: vitamin B12 cannot be overdosed In 2009, the Regional Disciplinary Medical Board in Eindhoven stated very clearly that an overdose is not possible: There can be no question of an overdose of hydroxocobalamin, as the excess is excreted in urine by the kidneys and therefore cannot accumulate in the body

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Cobalt supplementation may be required in some areas where Vitamin B12 deficiency occurs

Langan RC, Goodbred AJ American family physician 2017

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