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Microdosing GLP-1 Receptor Agonists During Perimenopause: A Clinical Approach to Hormonal Weight Gain Written and edited by Sarah Bonza MD, MPH, FAAFP, MSCP, DipABLM, NBC-HWC Perimenopause represents a challenging time for women, with up to 70% experiencing weight gain due to declining estrogen levels, decreased energy expenditure, and metabolic changes

Administration of either prazosin, a selective 1 -adrenergic receptor blocker, and propranolol, a -adrenergic receptor blocker, results in inhibition of the effects of FGF21 on the intoxicating effects of ethanol

Trulicity can cause weight loss, but the FDA has not approved it for this use

Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1

Comfort with taking the medication long-term, possibly for life

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