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2 Weight management matters for MS patients because excess weight can worsen symptoms, reduce mobility, and accelerate disease progression

It is approved as a supplemental therapy for overweight and obese adults, in conjunction with a calorie-restricted diet and enhanced physical activity in adults with a baseline BMI 30 or 27 kg/m with at least one weight-related comorbidity, across the USA, Canada, Europe, and the UK [10]

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So the same percentage deficit translates into more total calories cut, and more weight lost