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At the cellular level, our single-cell RNA sequencing data showed that semaglutide directly downregulated pro-fibrotic genes in hepatocytes (e.g., Col4a1 ), and reduced transcripts for extracellular matrix proteins in mesenchymal cells

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Notably, patients with minimal/mild endometriosis-associated infertility achieve lower success rates with stimulation and IUI compared to women with unexplained infertility, but ablation of minimal/mild endometriosis normalizes clinical pregnancy rates per cycle and cumulative birth rates, indicating that endometriosis exerts a reversible detrimental effect on fertility (11)

doi: 10.1016/j.phymed.2020.153305 [DOI] [PubMed] [Google Scholar] 72.Tu Q, Wang JF, Xie HQ, et al