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Besides, in H9c2 cardiomyocytes, GLP-1RAs also inhibit hypoxia-induced NLRP3 inflammasome activity and TNF- to attenuate pyroptosis through modulating the SIRT1/NADPH oxidase 4 (NOX4)/ROS pathway [139]

Our findings suggest that tirzepatide, through its dual GIP/GLP-1 action, may be superior as a non-IOPlowering adjunct or even as a primary preventive agent in glaucoma management among patients with diabetes, the researchers wrote in their paper

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Homozygous NKO mice exhibit embryonic lethality [68], whereas heterozygous NKO mice exhibit IGT due to impaired insulin secretion [68] and heart failure due to progressive mitochondrial dysfunction induced by pressure overload [69]