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If these stem cells are depleted or destroyed, reversing gray hair is theoretically much tougher to do

(PubMed) Stillwell W, Wassall SR

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J Neurochem 97(6):16761689 Goureau O, Regnier-Ricard F, Courtois Y (1999) Requirement for nitric oxide in retinal neuronal cell death induced by activated Muller glial cells

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Interestingly, serum biomarkers of nitric oxide metabolism were found to predict response to sapropterin treatment in children with ASD ( 4 supplementation may be specific to its effect on nitric oxide metabolism