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Retatrutide, because it activates three receptor pathways at once, may cause more gastrointestinal discomfort at higher doses

The researchers found that compared with topiramate, GLP-1 RA initiators had a lower risk for emergency department visits (risk ratio [RR], 0.90), hospitalizations (RR, 0.86), nerve blocks (RR, 0.87), and triptan use (RR, 0.87)