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Concurrently, advanced molecular therapeutics are emerging, including mitophagy inducers (e.g., urolithin A, nicotinamide riboside) to restore mitochondrial quality control (187, 188), gut microbiome engineering to reduce systemic inflammation (189), and innovative RNA therapeutics and gene circuits (e.g., olezarsen, the CHARM system) for long-term management of dyslipidemia (182, 183)

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372 Collectively, these findings reveal that targeting transcription factors such as TFEB, BRD4, FOXO, STATs, NF-B, and p53 enables precise autophagy modulation