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In Phase 1 and 2a clinical trials, once-daily subcutaneous injections of RG7697 (0.252.5 mg) for 14 days in 56 patients with T2DM and 1.8 mg of RG7697 for 12 weeks in patients with T2DM who were poorly responsive to metformin reduced body weight and improved glycemic control

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Pre-existing thyroid nodules, history of medullary thyroid cancer, or personal/family history of thyroid cancer are contraindications because animal studies showed C-cell proliferation

The weight loss in the semaglutide group was found to be significantly higher than in the liraglutide group [46]