The Phase 3 ATTAIN-1 trial had good results that led to this approval, but not all positive: 12.4% average weight loss (27.3 lbs) at highest dose Lower than the 15-20% weight loss seen with injectables Wegovy and Zepbound Nearly 1/4 of participants on the highest dose reported vomiting Vomiting rates are much higher than injectable GLP-1s However, there is likely a niche for Foundayo (along with the pill version of Wegovy) due to convenience: No refrigeration requirements or injection site reactions Eliminates barriers for patients avoiding injectables due to stigma, needle aversion, or storage constraints It's possible we could see this as a "maintenance" therapy after an initial injectable course
PlexusDx offers compounded tirzepatide injections at $289/mo month-to-month, or from $249/mo on the 6-month plan and can help determine if a switch is warranted
LBA 31 Wojtaszewski, J
The pharmacy will prepare the medication under controlled conditions, ensuring accurate dosing and ingredient purity
How Genetic Predispositions May Inform Your PCP Conversation The PlexusDx Precision Peptide Genetic Test analyzes GLP1R, GIPR, FTO, and MC4R variants that relate to GLP-1 and related signaling pathways
Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins
