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In rare cases, certain drugs used to treat CVD, such as statins or angiotensin converting enzyme (ACE) inhibitors, may cause hair loss

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Compared with DKD patients without SGLT2is or DPP4is, urine Na/Cre, urinary Na concentrations, and urine Na/K were significantly higher in combination therapy, but not patients with SGLT2is treatment alone (Fig

Although it is presently unresolved whether the gut microbiota plays a role in the effects of these peptide hormones, it has been speculated that host-gut microbiota crosstalk, facilitated by the production and signaling of bacterial fermentation end-products of dietary fibers (short-chain fatty acids), influences intestinal chemo-sensing and modulates the release and activity of gut peptides 27,28,29,30

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