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S., Arnold, K., Mackenzie, C., et al

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The inconsistent results may be due to the low incidence and the incorporation of studies with limited sample sizes, statistical effectiveness was not greatly increased

Events such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in individuals with MetS may contribute to the activation of the innate immune response, which compromises cerebral microcirculation and the neurovascular unit, leading to the onset or progression of neurodegenerative diseases

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ABSTRACT Coffee enemas are believed to cause dilatation of bile ducts and excretion of bile through the colon wall