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In a large, multicentre, RCT with selenium, patients with mild Graves orbitopathy significantly improved on treatment with 100 g selenium twice/d (as sodium selenite) for 6 months ( Reference Marcocci, Kahaly and Krassas 7 )

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Recently, also, the modification of the redox state of cysteine residues of certain proteins, which is a widespread mechanism in the regulation of protein function, has been proposed to be involved in signaling pathways