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CNS-expressed GIPR mediates independent weight loss effects Beta-cell function preclinical and clinical data indicate improved beta-cell mass preservation over time Lipid metabolism reduces hepatic fat content and improves adipose tissue lipolytic activity Research Areas Tirzepatide is studied in type 2 diabetes, obesity, NASH, cardiac outcomes, and incretin biology

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Written informed consent to participate in this study was provided by the participants' legal guardian/next of kin

Instead, the body draws from both fat and muscle