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Studied together, the pairing has shown meaningful improvements in HbA1c, in insulin resistance markers such as HOMA-IR, and in fat mass over roughly 52 weeks of therapy, which makes it one of the best-established and lowest-risk combinations in modern diabetes care [4]

The published Phase 1, Phase 2, and Phase 3 clinical evidence supporting the November 10, 2010 FDA approval (Falutz 2007 NEJM

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Originally developed to manage diabetes, these medications began showing significant weight reduction in clinical trials