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Ferreira JP, Neves JS (2022) Glucagon-like peptide 1 receptor agonists in heart failure: the need for a rewind
The trial evaluated multiple dosing cohorts with an escalation schedule designed to minimize gastrointestinal side effects during the initial weeks of treatment: Key Observations From Retatrutide Dosage Data Dose-dependent response Weight reduction increased in a clear dose-dependent pattern across all cohorts
Clinical Evidence Injection-site reactions and other adverse events must be interpreted from specific trial data
Wadden TA, Hollander P, Klein S, Niswender K, Woo V, Hale PM et al (2013) Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study
GLP-1 receptor (GLP-1R) agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte (IEL) GLP-1R