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Walter Swardfager is supported by the Canada Research Chairs Program (Award Number: CRC-202400213), the Ontario Ministry of Colleges and Universities (Award Number: ER21-16146), the Dr

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How It Happens GLP-1 agonists: Suppress appetite Reduce caloric intake Slow gastric emptying Promote weight loss As food intake drops, patients may: Reduce their insulin doses to avoid hypoglycemia Experience more frequent low blood sugar episodes Intentionally decrease insulin in response to lower carb intake But heres the critical issue: Insulin Suppresses Ketone Production Insulins role isnt only to lower glucose

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Both combinations leverage cagrilintide's amylin pathway activation, but they differ significantly in their complementary mechanisms