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doi: 10.1002/anie.201602525 89 LiJ.ZhaoL.WangZ.ZhaoX.WuJ

In the chronic kidney disease (CKD) state, declining renal function leads to substantial urea excretion into the intestinal tract, where it is hydrolyzed by microbial urease to ammonia, converting to ammonium hydroxide and elevating luminal pH (100)

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For the diet-induced obesity cohort, food was withdrawn 3 days per week for 24 h each, with alternating ad libitum HFD feeding days