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Activation of synaptic NMDARs can induce neuronal survival through Ca 2+ -mediated signal transduction pathways, whereas overactivation of extrasynaptic pathways can induce neuronal death (Stefanie et al., 2010)

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Use is restricted to qualified professionals in controlled scientific environments.

There are also differences in the transcriptional profiles of rodent and human immune systems (Shay et al., 2013), and studies of inflammatory diseases using rodents often poorly translate to humans (Mestas and Hughes, 2004

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