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Telehealth pricing tends to be higher than going directly to a compounding pharmacy because it bundles clinical services

20 However, a retrospective single-institution study showed that although other anti-diabetic medications (such as sodium-glucose cotransporter 2 inhibitors) were associated with a lower risk of sight-threatening DR, GLP-1RAs were not shown to confer any increased DR risk, clinical worsening, or increased intervention in DR

They require medical supervision, with NICE providing specific guidance on their use in type 2 diabetes (NG28) and obesity

They are prescribed only when a commercial product isnt available or medically appropriate for an individual patient

Tirzepatide (sold as Zepbound for weight loss, Mounjaro for diabetes) produces the most weight loss of any approved drug: about 22.5%

Second, Chen said the development of new multidimensional tools such as the Cardiometabolic Efficacy Index (CEI) may help move the field toward more personalized treatment selection