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A randomized controlled trial (NCT04111775) demonstrated that oral charcoal adsorbent AST-120 reduces serum IS concentrations by 58% and decreases the urinary protein-to-creatinine ratio by 29% after 12 weeks, providing evidence that targeting gut-derived uremic toxins offers potential therapeutic benefits for established DN (28, 29)

Appropriate laboratory tests to establish hematological and serum biochemical baseline data prior to, and periodically during, administration of any NSAID should be considered

Pushing doses up too fast is the single biggest cause of dropping out

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