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Recently, Lynch et al

This metabolic state arises from a dysregulation between uric acid production and elimination, culminating in its accumulation in the bloodstream

If you carry reduced-function variants, your baseline enzyme activity is already lower before any dietary or lifestyle factors enter the picture

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All housing, handling, and experimentation that involved the rats were conducted following the procedures set in place by the National Institutes of Health guide for the care and usage of laboratory animals [2]

Currently, this tool has been applied only in a few observational studies