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ClinicalTrials.gov (2017)

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If a medication isnt effective, options include adjusting the dosage, switching to a different weight loss drug, or exploring alternative treatments such as metabolic testing, personalized nutrition plans, or behavioral therapy, Best told Healthline

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Animal trials testing injecting GLP-1 drugs into arthritic joints have also been undertaken

He also looks like he has the facial effects, in case you missed one of the myriad daily updates of his appearance broadcast to every Internet user in the world he is looking increasingly gaunt of late