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Aronne and published in the New England Journal of Medicine

These results are particularly striking given that participants had diabetes for an average of 8 yearsoften a more resistant group

1 However, it is recommended to avoid use in patients with a personal or family history of MTC and in patients with multiple neoplasia syndrome type 2

DPP-4 inhibitors can on the other hand also be combined with an oral therapy with a SGLT-2 inhibitor (in dual combination when metformin is contraindicated or not tolerated or in triple therapy with metformin)

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[20] Without medical supervision, individuals with diabetes taking such medications face a meaningful risk of low blood sugar episodes