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Other first-generation GLP-1 medications include liraglutide, a synthetic form of the peptide with fatty acids attached for increased stability

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The guidelines underscore that these medications should be chosen in the right context and in the right conditions

Phase 3 trials are ongoing and retatrutide remains unapproved for routine clinical use

GLP-1, GIP, exendin-4 and liraglutide had suppressive effects on oxLDL-induced foam cell formation, which is linked with the suppression of infiltrated macrophage foam cells in atherosclerotic plaques, resulting in repressed atherosclerotic plaque formation

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