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At least in hippocampal HT22 cells and in the hippocampus of wild type mice, the transcriptional control of most of these Gpx4 isoforms is modulated by DHA following an unprecedented homeostatic strategy aimed to buffer its potential oxidation and to ensure its preservation in the hippocampal neuronal membrane

The clinical development program established five dose tiers: 2.5mg, 5mg, 7.5mg, 10mg, and 15mg, administered once weekly via subcutaneous injection

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Even GHK-Cu has antioxidant and anti-inflammatory properties mediated through superoxide dismutase activation