Users and researchers have documented effects across several domains of health and performance, though it bears mentioning that much of this evidence comes from animal studies, small human trials, or anecdotal reports rather than large-scale clinical trials
Westfall TC et al (2018): Adrenergic agonists and antagonists
Proc Natl Acad Sci USA 99 : 77467750
Possibly, this toxicity, in addition to lower esophageal sphincter and pyloric sphincter failure, involves sole NSAIDs-gastric ulcers, presenting with aspirin (and thereby, aspirin was used intragastrically) (14) and ibuprofen (10), as well as with those agents combining gastric and small intestine ulcers (i.e., diclofenac (9, 11))
doi: 10.1152/ajplung.1993.264.1.L80
Individual results vary depending on skin type and routine consistency