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Our findings support this hypothesis, as increases in vitamin D and reductions in cortisol and CRP persisted after weight adjustment, whereas changes in glucose, HbA1c, insulin, HOMA-IR, HDL, and other metabolic markers appeared to be predominantly mediated by weight loss.12,28,29 In 2017, the first case was published describing a patient with refractory HS, obesity, and type 2 diabetes who experienced improvement in dermatologic lesions following treatment with liraglutide.19 Subsequent prospective case series further explored this therapeutic strategy, although these cohorts consistently included patients with type 2 diabetes, and liraglutide doses were therefore lower than those approved for obesity management

Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies

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Across all STEP trials, the consistent finding was 14.9% to 17.4% average body weight reduction at 68 weeks with the 2.4 mg dose