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The reasons: The mechanism is complementary to GLP-1 agonists
doi: 10.1007/s12011-015-0433-1 69
Ipamorelin: Ipamorelin is a selective growth hormone secretagogue (GHS) that interacts with GHRP receptors, promoting natural GH release without significantly affecting prolactin or cortisol levels
Fatigue affects 5-11% of patients and typically results from substantial caloric restriction due to appetite suppression, gastrointestinal side effects like nausea and vomiting, dehydration from reduced oral intake, or rapid metabolic changes during weight loss
The authors noted that human research remains limited to small pilot studies, and that no major adverse effects have been reported in published animal or early human work
That is rare
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