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Clinical Decision Summary Patients and clinicians weighing Mounjaro versus retatrutide face a choice between an approved, commercially accessible drug with 72-week phase 3 data and an investigational agent with 48-week phase 2 data that shows numerically superior weight loss but substantially higher GI discontinuation rates

Unlike pre-mixed medications, Retatrutide typically comes as a freeze-dried powder that requires reconstitution before use

A workable treatment plan Anna Olson says this kind of personalization was key

Convenient telehealth and messaging access: All medical visits take place online, and you can message your clinician anytime through the app for check-ins, updates, or guidance on your schedule

This can lead to weight loss that is primarily fat, not muscle

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