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When this cardiometabolic benefit slide was shown there was audible murmuring and comments

GLP-1 medications can increase surgical risks, as they slow down digestion and delay stomach emptying, potentially leading to complications under anesthesia

The other 40% either cycle between periods on and off medication, or attempt lifestyle maintenance alone

and retatrutide is a triple GIP/GLP-1/glucagon agonist and one of the most-studied next-generation candidates

The medication is able to make maintaining a calorie deficient diet significantly easier by slowing down digestion, which communicates to the brain that it feels fuller for longer, resulting in a reduced appetite

The starting dose of retatrutide and optimal dose selection will likely be refined further when FDA labeling is finalized