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Muscle preservation is not equally important for everyone

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Losing weight too quickly could be a red flag for muscle loss and bone mineral density

In the physiological context, our convergent data from intra-OB Ex9, IPGTT and ex vivo OB GLP-1 release experiments indicate local production of GLP-1 in the OB, presumably independently of peripherally derived GLP-1

They found that the GLP-1R component was a primary driver of reduced food intake and slowed gastric emptying, while the GIPR component appeared to enhance the effects on insulin sensitivity and potentially modulate fat metabolism within adipose tissue

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