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The Efficacy Gap: Oral vs Injectable Injectable tirzepatide (Zepbound), a dual GLP-1 and GIP receptor agonist, produced weight reductions of between 16% and 22.5% over 72 weeks in the SURMOUNT trials

When prescribed and monitored by a qualified medical professional, peptides are generally considered safe for long-term use

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In addition to blunted monoaminergic neurotransmission, it was also shown that deficiency in neurotrophic factor effects, disturbances in neurogenesis and synaptogenesis, chronic neuroinflammatory processes, and dysregulation of the hypothalamicpituitaryadrenal (HPA) axis can largely contribute to the manifestation of depressive symptoms in patients [3,4,5]

At rest, muscle burns roughly 6 kcal per pound per day , while fat burns about 2 kcal per pound per day

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