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Compound 102 exhibited overt suppression of ROS accumulation in a dose-dependent manner with an EC 50 of about 11.4 M (fluorescent intensity determined by ImageJ and a plate reader, Supplementary Figures S7 , S8 )
APAP hepatotoxicity occurs through formation of the noxious NAPQI metabolite, which is present in excessive quantities, as augmented by features of glutathione (GSH) depletion, oxidative stress and mitochondrial dysfunction leading to depletion in adenosine triphosphate (ATP) stores
coli gshB mutant optimized according to codon usage of S
Given the established role of FXR activation in suppressing lipid peroxidation and the critical importance of granulosa cell integrity for follicular development, BAs may represent important endogenous regulators of ovarian function in PCOS
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