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Wiernicki et al., 2020

Swine : 2.5 -10 ml

Epigallocatechin gallate, a polyphenolic component of green tea, inhibits the progression of various cancers, including glioma, breast and liver cancers, by inhibiting IGF-1R via the phosphorylation of the tyrosine kinase IGF-1R (118120)

10.3390/antiox9080647 200 PlavoukouT.IosifidisM.PapagiannisG.StasinopoulosD.GeorgoudisG

Similar to CM, the MAPK cascade is hyperactivated by altered genes in MM including NRAS , BRAF , NF1 , and SPRED1 , thereby making inhibition of MAPK signal transduction a promising treatment strategy for MM patients

In summary, long-acting GLP-1R agonists primarily reach the circumventricular organs of the hindbrain and food-intake controlling centers of the hypothalamus