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Although the steric bulk of the (CH 2 )3 side chain might diminish activity relative to the natural GLP-1R agonists, these replacements should test the hypothesis that GLP-1R agonist activity is higher for ligands that can access non-helical conformations near the N-terminus, compared to those that cannot

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Moreover, GLP-1 RAs also exert beneficial roles on multiple organ systems in which the GLP-1 receptors exist, including the cardiovascular system

That means the drug could be acting on the tumor itself, not just shrinking the patient, she said