Preclinical studies in rodents have identified a potential signal for thyroid C-cell tumours with GLP-1 receptor agonists
Specifically, DPP-4 cleaves the peptide bond between Ala 8 -Glu 9 resulting in the abundant GLP-1 (936) amide constituting 6080% of total GLP-1 in circulation
The positive impact of GLP-1RA therapy on lipids is an important contributor to these outcomes
2.5 Discontinuation for Iodinated Contrast Imaging Procedures Discontinue XIGDUO XR at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR less than 60 mL/min/1.73 m2, in patients with a history of liver disease, alcoholism or heart failure
In December 2025, the World Health Organization (WHO) issued new guidelines recommending GLP-1 medications to help treat obesity
Each batch is characterised by reversed-phase HPLC (99%) and identity-confirmed by mass spectrometry