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(PubMed) Trpkovic A, Resanovic I, Stanimirovic J, et al

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3.3.2 Role of MOTS-c in OPG/RANKL-mediated osteoclasts In a UHMWPE model-induced osteolysis mouse model, MOTS-c was found to increase the intracellular osteoprotegerin (OPG)/RANKL ratio in osteocytes, thereby inhibiting osteoclastogenesis