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In general obesity, pioglitazone improved IR and caused a lowered waist-to-hip ratio via increasing lower body AT without changing VAT in general obesity [47]

Furthermore, roGFP2 fusion constructs with wild-type and mutant enzymes allow the intracellular analysis of enzyme mechanisms and structure-function relationships 15,34,35,75

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Thats why its important to make gradual, sustainable nutrition changes while on the medication, like eating more protein to preserve muscle, choosing fiber-rich foods to support fullness, and building balanced meals

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