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Puddu et al

Purpose The purpose of this systematic review is to summarize data on drug-drug interactions between GLP1RAs and oral drugs

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Furthermore, it provides a critical appraisal of recent human observational data, distinguishing metabolic benefits from intrinsic disease-modifying effects, and outlines the practical clinical friction points and prospective trials necessary to validate these pathways in future treatment paradigms

An important caveat is that we used mini-G proteins in our assays, which do not consider the role of the -subunits

pal GHK (Palmitoyl Tripeptide-1)