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The sequences of primer pair 2 used were as follows: 5-GTTCTCCGTTTGCACTCAGG-3 (sense) and 5-CAGGTTCTTGCGAACCTCAT-3 (antisense) (Cre amplicon: ~500 bp)
Lipodystrophy Long-term use of insulin, including TOUJEO, can cause lipoatrophy (depression in the skin) or lipohypertrophy (enlargement or thickening of tissue) in some patients and may affect insulin absorption [see Dosage and Administration (2.1)]
About 20-30% of patients have minimal or no side effects
Arrhythmia, irregular heartbeat, palpitations, rapid heartbeat, or rhythmic heartbeat Pulsatile tinnitus, hearing a ringing or whistling sound in one ear, alternating back and forth like the sound of cicadas screeching loudly
It may thus lay a basis for further studies using electronic health records or patient-reported data with the purpose of understanding who the potential off-label patients are and to what degree they benefit from treatment
