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Although Bbs5 / mice showed no differences in body weight at weaning compared to age-matched WT or heterozygous littermate controls, the KO mice began gaining adiposity at a significantly faster rate after 4 weeks of age, eventually becoming visibly larger than mice in both control groups (Figure 1A) Bbs5 / mice exhibited significant hyperphagia in both the light and dark phases compared with WT controls (Figure 1B), leading to increased body weight from 8 weeks of age (Figure 1C) and fat mass compared with WT littermate controls starting from 6 weeks of age (Figure 1D)

Both compounds offer meaningful benefits, but their different profiles suit different priorities

Future work will assess the safety of BITC on human gum cells to further validate its clinical potential

PowerSkulpt starts with recovery

Because retatrutide loses more total weight (up to ~24.2% in Phase 2), the absolute lean-mass loss can be larger even at a similar percentage

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