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Comparative interpretation should therefore consider the complete concentration-response profile, including potency, maximal efficacy, curve shape, receptor expression, assay timing, and albumin or serum-protein conditions
This may be largely attributable to the mechanism of action of the agents, the metabolic adaptation in patients, and the cumulative effects during long-term therapy (57)
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Others may be candidates for oral formulations, microdose protocols, or additional peptide support based on genetic testing results