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Yosefy O, Sharon B, Yagil C, Shlapoberski M, Livoff A, Novitski I, Beeri R, Yagil Y, Yosefy C

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Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor- (TNF-), along with hypoxic stress, oxidative damage, and uremic toxins, have been shown to suppress the expression and activity of CYP27B1 through multiple signaling pathways, resulting in reduced synthesis of 1,25(OH)D (16)

IL-6, interleukin-6