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LY3437943 demonstrated a safety and tolerability profile equivalent to other incretins in a phase 1 single ascending dosage study

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Our results align with these findings, highlighting the importance of such monitoring to prevent potential complications

We will focus this review on the IGF-1 receptor (IGF-1R), but both insulin and IGF-2 (11), can also signal through this receptor, albeit with lower affinity

- [SURMOUNT-1: Tirzepatide Once Weekly for the Treatment of Obesity]( *New England Journal of Medicine*, 2022