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Although ICH Q2(R2) is primarily intended for pharmaceutical analytical procedures, its fit-for-purpose validation principles may be used as a non-mandatory scientific reference for research-reagent testing

Nausea, diarrhea, constipation, and reduced appetite dose-dependent and concentrated early and just after dose increases

Timeline varies individually based on starting skin condition, metabolism, lifestyle factors

This includes the cost of Botox

If the dose is too high, some users report lethargy or fatigue, likely due to hormonal shifts because it interacts with the ghrelin pathway and can increase appetite, especially when starting the medication