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Weight loss medications such as Wegovy, Mounjaro, Saxenda, and Orlistat help reduce appetite, regulate glucose levels, and support weight loss goals

For women using estrogen-containing or progestin-only oral contraceptives, Topiramate may reduce contraceptive efficacy

As tolerance improves, patients can gradually reintroduce higher-fiber foods and expand dietary variety while monitoring symptoms

Oral semaglutide showed cardiovascular safety profile, with significant reduced risk of death from cardiovascular events

Thus, is it reasonable to proceed as usual, as the guidance states

Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks