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The risks of renal impairment, volume depletion adverse reactions and urinary tract infection-related adverse reactions increased with worsening renal function [see Warnings and Precautions (5.2)]

Based on the systematic review[16] and meta-analysis[21] of 37 randomized controlled trials, the dosage range for L-carnitine supplementation varied between 250 mg/day to 4000 mg/day