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Sikiric, P., Seiwerth, S., Ruman, R., Turkovi, B., Rokotov, D., Bri, L., Sever, M., Klicek, R., Radi, B., Drmic, D., Ili, S., Kolenc, D., Stambolija, V., Zorii, Z., Vri, H., & ebei, B

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Unlike NAD+ precursors that work downstream, 5-Amino-1MQ acts upstream by blocking NNMTs consumption of S-adenosyl methionine (SAM), resulting in elevated intracellular NAD+ and SAM levels without requiring direct nucleotide supplementation

Early-phase clinical trials including a Phase 2 dose-ranging study published in the New England Journal of Medicine (2023) have demonstrated significant potential for weight reduction and metabolic improvement, generating considerable scientific interest

And while that can be true, it also introduces complexity